スーパータダライズについて
Tadalafil 20 mg is an FDA-approved phosphodiesterase-5 inhibitor used in the treatment of erectile dysfunction and benign prostatic hyperplasia. Phosphodiesterase enzymes are a group of enzymes responsible for regulating cyclic adenosine monophosphate and guanosine monophosphate levels, which are crucial in regulating inflammation and helping blood vessels relax in addition to performing other functions.
In the process of exerting their therapeutic functions, PDE enzymes degrade or breakdown cGMP that promotes erectile response to sexual stimulation, giving rise to symptoms of erectile dysfunction in the form of occasional or complete inability to initiate or maintain an erection, less frequent or less firm erections with resulting anxiety or stress because of unsatisfactory sexual performance.
Tadalafil inhibits the phosphodiesterase enzymes, degrading the cGMP levels and improving and regulating its levels. The result is increased levels of cGMP levels that relax the smooth muscle cells in the corpus cavernosum and increase blood flow to the penile muscles to initiate a successful and long-standing erection.
Tadalafil as an Anti-Aging Medication
It is important to understand that increased activity of the cGMP levels through the inhibition of phosphodiesterase enzymes does not limit increased blood flow to the penile regions but even to the endothelial regions, resulting in a regulated blow to the heart, preventing platelets from clumping together.
The result is reduced atherosclerosis and improved wound healing, with an overall reduced risk of fatality associated with cardiovascular issues related to Tadalafil use.
Animal studies have shown that the medication has the potential to increase the survival of failing skin grafts and help in oxygen flow during the healing process.
Chronic treatment with Tadalafil 20 mg can improve the content of collagen and enhance skin quality while reducing the intensity of scarring.
Currently, Tadalafil is FDA-approved for Erectile Dysfunction and Benign Prostatic Hyperplasia conditions, with its anti-aging properties being researched and evaluated extensively.
How to use Tadalafil for ED conditions
Tadalafil is available in multiple strengths out of which 10 mg and 20 mg are the preferred strengths for erectile dysfunction conditions. Usually, the strength of Tadalafil best suited for ED is determined by keeping in mind factors like
- Age of the patient
- Severity of ED symptoms
- Tolerance to Tadalafil or its higher strengths
Tadalafil 20 mg is advised for people with severe ED symptoms that are not improving with lower strengths or with other PDE-5 inhibitors.
The medication takes 30 -60 minutes to set in and has a good bioavailability, i.e., it is not impacted by food intake. For safe use, physicians advise using Tadalafil at least an hour before sexual activity and avoiding heavy, greasy foods and alcoholic and caffeinated beverages along with it.
Precautions
Some of the things that you need to be careful about with Tadalafil use are
- Tadalafil use can result in drug interactions when used with alpha-blockers and nitrates. Discuss your systemic history with your healthcare provider before using the medication
- Avoid using it alongside other PDE-5 inhibitors like Sildenafil as it can lead to overdosing symptoms in the form of breathlessness and priapism( painful erection)
- Tadalafil use is designed for males and can result in adverse reactions when used in females
- Individuals who have a history of heart problems or who have recently undergone heart surgery should avoid using the medication
- The medication is contraindicated in people allergic or hypersensitive to Tadalafil or its ingredients
Most importantly, if the complications increase in severity or intensify with Tadalafil use, discontinue the medication immediately and get urgent medical attention.
Side effects
Some of the common side effects associated with Tadalafil use are headache, nausea, facial flushing, a stuffy nose, and indigestion.
For safe usage, physicians advise using it on an empty stomach and using sufficient water to gulp it down.
Rarely, Tadalafil use can lead to adverse reactions in the form of low blood pressure, vision loss, hearing loss, and back pain.
Discuss with your healthcare provider your systemic history and the possibility of complications with Tadalafil use to avoid serious complications
Alternatives
Some of the alternatives to Tadalafil for treating Erectile dysfunction are
Sildenafil – available under the brand name of Viagra, Sildenafil is taken orally at least an
hour before sexual activity and lasts for four to five hours
Avanafil – Avanafil is taken fifteen to thirty minutes before sexual activity and lasts for five to six hours
Vardenafil – Vardenafil is required to be used an hour before sexual activity and lasts for five to seven hours after a dose
Alprostadil – Can be Taken ten to thirty minutes prior to erectile activity that lasts for thirty to sixty minutes.
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